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Check Closely (one)phenobarbital will decrease the level or effect of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Coadministration of fentanyl with CYP3A4 inducers may lead into a minimize in fentanyl plasma concentrations, deficiency of efficacy or, possibly, development of the